Publications

HAND1, partially mediated through ape-specific LTR binding, is essential for human extra-embryonic mesenchyme derivation from iPSCs
Cell reports, 2025 Apr 22;44(4).
Liu Z, Tan Y, Flynn WF, Sun L, Pratumkaew P, Diniz JA, Oliveira NA, McDonough JA, Skarnes WC, Robson P
JAXDPC
PMID: 40220298
MorPhiC Consortium: towards functional characterization of all human genes
Nature, 2025 Feb 13;638(8050):351-9.
Adli M, Przybyla L, Burdett T, Burridge PW, Cacheiro P, Chang HY, Engreitz JM, Gilbert LA, Greenleaf WJ, Hsu L, Huangfu D
All
PMID: 39939790
Comparative analysis and directed protein evolution yield an improved degron technology with minimal basal degradation, rapid inducible depletion, and faster recovery of target proteins
Research Square, 2024 Nov 15;rs-3.
Adli M, Xing D, Bai T, Neyisci O, Paylakhi S, Duval A, Tekin Y
NWUDPC
PMID: 39606491
Parallel genome-scale CRISPR-Cas9 screens uncouple human pluripotent stem cell identity versus fitness
Nature communications, 2024 Oct 17;15(1):8966.
Rosen BP, Li QV, Cho HS, Liu D, Yang D, Graff S, Yan J, Luo R, Verma N, Damodaran JR, Kale HT
MSKDPC
PMID: 39419994
Single-nuclei sequencing of uterine serous carcinoma reveals racial differences in immune signaling
Proceedings of the National Academy of Sciences, 2024 Aug 20;121(34):e2402998121.
Foley KG, Adli M, Kim JJ
NWUDPC
PMID: 39133838
Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism
Genome biology, 2024 Mar 22;25(1):77.
Pujadas Liwag EM, Wei X, Acosta N, Carter LM, Yang J, Almassalha LM, Jain S, Daneshkhah A, Rao SS, Seker-Polat F, MacQuarrie KL
NWUDPC
PMID: 38519987
Integrating leiomyoma genetics, epigenomics, and single-cell transcriptomics reveals causal genetic variants, genes, and cell types
Nature communications, 2024 Feb 7;15(1):1169.
Buyukcelebi K, Duval AJ, Abdula F, Elkafas H, Seker-Polat F, Adli M
NWUDPC
PMID: 38326302
Biology-driven therapy advances in high-grade serous ovarian cancer
The Journal of Clinical Investigation, 2024 Jan 2;134(1).
Wang Y, Duval AJ, Adli M, Matei D
NWUDPC
PMID: 38165032
Engineered MED12 mutations drive leiomyoma-like transcriptional and metabolic programs by altering the 3D genome compartmentalization
Nature communications, 2023 Jul 10;14(1):4057.
Buyukcelebi K, Chen X, Abdula F, Elkafas H, Duval AJ, Ozturk H, Seker-Polat F, Jin Q, Yin P, Feng Y, Bulun SE
NWUDPC
PMID: 37429859
Adenomyosis: single-cell transcriptomic analysis reveals a paracrine mesenchymal–epithelial interaction involving the WNT/SFRP pathway
Fertility and sterility, 2023 May 1;119(5):869-82.
Yildiz S, Kinali M, Wei JJ, Milad M, Yin P, Adli M, Bulun SE
NWUDPC
PMID: 36736810
Endometriosis and adenomyosis: shared pathophysiology
Fertility and Sterility, 2023 May 1;119(5):746-50.
Bulun SE, Yildiz S, Adli M, Chakravarti D, Parker JB, Milad M, Yang L, Chaudhari A, Tsai S, Wei JJ, Yin P
NWUDPC
PMID: 36925057

News

"MorPhiC: Cellular modeling at scale" - JAX speak about their role in the MorPhiC Consortium

Looking beyond suspect genes in cancer

Figuring Out What Genes Do

Towards the Functional Characterization of All Human Genes

A new publication in Nature: "MorPhiC Consortium: towards functional characterization of all human genes"

Bioinformatics Team Powers International Effort to Map Gene Function

The Molecular Phenotypes of Null Alleles in Cells program seeks to identify the purpose behind every gene.

Identifying How Genes Function to Better Understand Cancer with Mazhar Adli, PhD

NIH initiative to systematically investigate and establish function of every human gene

Publications

HAND1, partially mediated through ape-specific LTR binding, is essential for human extra-embryonic mesenchyme derivation from iPSCs

MorPhiC Consortium: towards functional characterization of all human genes

Comparative analysis and directed protein evolution yield an improved degron technology with minimal basal degradation, rapid inducible depletion, and faster recovery of target proteins

Parallel genome-scale CRISPR-Cas9 screens uncouple human pluripotent stem cell identity versus fitness

Single-nuclei sequencing of uterine serous carcinoma reveals racial differences in immune signaling

Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism

Integrating leiomyoma genetics, epigenomics, and single-cell transcriptomics reveals causal genetic variants, genes, and cell types

Biology-driven therapy advances in high-grade serous ovarian cancer

Engineered MED12 mutations drive leiomyoma-like transcriptional and metabolic programs by altering the 3D genome compartmentalization

Adenomyosis: single-cell transcriptomic analysis reveals a paracrine mesenchymal–epithelial interaction involving the WNT/SFRP pathway

Endometriosis and adenomyosis: shared pathophysiology